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An inflammatory process initiated by environmental antigens or superantigens may result in apoptosis of infiltrating inflammatory cells, thereby allowing for a temporal transition to the chronic phase of lupus erythematosus. This may be accompanied by the production of autoantibodies, the specific components of which are unknown. The mechanisms of inflammation, apoptosis and autoimmunity are discussed in relation to cutaneous lupus erythematosus.Leukotriene receptor antagonists as therapy for the common cold. Because the common cold is a very common respiratory illness affecting most of the population worldwide, it is important to develop new therapeutic strategies to treat it. Leukotriene receptor antagonists are a new and highly selective class of anti-inflammatory compounds which block not only the effects of leukotrienes but also those of other eicosanoids which stimulate immune and airway responses. To assess the efficacy of leukotriene receptor antagonists (pranlukast and zileuton) compared to placebo, antihistamines and standard therapy (2 lysine-acetylsalicylic acid tablets once daily) in adults with the common cold. A MEDLINE search was performed for English-language trials of pranlukast and zileuton that used a single dose compared to placebo, standard therapy or antihistamines for the treatment of the common cold. Trials were included if they were conducted on adults only and had reported time to recovery from the cold as an endpoint. Patient characteristics were age, sex, smoking status, disease severity, exclusion criteria, drug dose, drug type, comparators and trial duration. The literature searches were updated and all new trials identified from the search on the Internet were reviewed. Data were retrieved for all articles and information was extracted using a predetermined format. 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